Spravato (Esketamine)

Novel treatment options

Spravato for Treatment Resistant Depression

Depression is a potentially debilitating illness that has a functional, economic, and emotional impact on both the patient and their family. The situation is bad for those who fail to show improvements with standard treatments. At its worst, depression can lead to suicide. Close to 800 000 people die due to suicide every year. Suicide is the second leading cause of death in 15-29-year-olds.

A report shows that one-third of US adults suffering from major depressive disorder have treatment-resistant depression. This means, these patients do not respond to at least two different antidepressants over a period of time. If you are one of those or you know somebody who is going through this phase, it is important to stay updated about the latest medications.

SPRAVATO is an FDA approved oral spray by Janssen Pharmaceutical Company that can be used with oral depressants for people struggling through treatment resistant depression.

People who took SPRAVATO in both short and long term clinical trials noticed a considerable improvement in the symptoms of depression and other symptoms compared to the patients who only received oral antidepressants and placebo. A study shows that people who took SPRAVATO besides the antidepressants were 51% less likely to relapse.  

Why does SPRAVATO work?

SPRAVATO is the first to use the newer mechanism of action to treat major depressive disorder. It works on the NMDA (N-methyl-D-aspartate) receptor.  It is an ionotropic glutamate receptor present in the brain. The medicine is taken as a nasal spray, which is quickly absorbed by the nasal passage lining and into the stream of blood. Thus, offering desired results.

How to go about SPRAVATO treatment?

Once the physician has given a go ahead about this treatment option, you need to visit a certified center that is trained to administer the medicine and address the needs of the patients. As the medicine is not to be dispensed directly for home use to the patients, it needs to be taken under the supervision of a healthcare provider. The healthcare provider decides the dosage and frequency of the medicine keeping your present condition in consideration. For best results, it is important to stay on the schedule given by the doctor. If you miss a dosage, the healthcare provider might have to change the treatment schedule and dose.

 After the medicine, the healthcare provider observes the patient for the following conditions:

·      Treatment emergent sedation

·      Change in blood pressure

·      Dissociation

·      Bladder problems

·      Fatigue

·      Spinning sensation

Only after two hours may the patient leave but is advised not to drive or operate heavy machinery for at least 24 hours.

Will it be covered in insurance?

If you are confused whether the treatment will be covered in your insurance or not, you can take help of the Janssen CarePath support plan. It helps patients get started and motivate them to stay on track. The company also provides information on insurance coverage, treatment support and estimated out-of-pocket costs. The company even helps make the treatment affordable for commercially insured patients.

It is important to tell the healthcare provider about all the medication and treatment you are taking including the over-the-counter drugs, prescribed medicines, herbal supplements, and vitamins. 

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